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Diet Board as Strategy to Development of Fetal Programming on Female Rats
Author(s) -
KANUNFRE CARLA,
Oliveira Larissa,
Costa Nathalia,
Lecke Sheila,
Morsch Debora,
Spritzer Poli
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb654
Subject(s) - offspring , lactation , weaning , medicine , endocrinology , pregnancy , weight gain , gestation , insulin , biology , fetus , adipose tissue , body weight , genetics
Controlled animal studies supply an important correlation between maternal nutrition (during pregnancy and lactation) and risk of disease in later life of offspring. Here we report the use of diet board as strategy to development of fetal programming and the effects produced in mothers and female offspring postnatal fed or not with hypercaloric diet. The diet board consisted of two aspen boards placed into the rat cage with vertical holes filled with food pellets, the unique way the rats obtained feed. Wistar pregnant dams were randomized into one of two groups, control and diet board. At weaning, female offspring were randomly assigned to receive either standard rat chow or hypercaloric diet (17%Kcal of sucrose, 10%kcal of primex shortening). The diet board reduces the weight gain on lactation (p=0.004) and gestation length (p=0.04). In addition mothers fed by diet board presented lesser fat in the adipose tissue depots (p=0.02). Concerning to effects of diets in the postnatal period, offspring did not differ on growth, energy intake, final body weight, Lee index and levels of insulin. In turn, hypercaloric diet had effects on visceral fat that was confirmed by adiposity index (p=0.01), glucose concentration (p=0.009) and ipITT (p=0.006). These data indicate that diet board as strategy to development of fetal programming produces effects on mothers that have impact on insulin and glucose tolerance of adulthood offspring manifested in the animals fed with hypercaloric diet. Grant Funding Source : Brazilian National Institute of Hormones and Women's Health and FIPE – HCPA, Brazil.