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Effects of Pamidronate in Acute Cardiotoxicity Induced by Doxorubicin in Rats
Author(s) -
Polegato Bertha,
Carvalho Paula,
Bergamasco Carolina,
Gonçalves Andrea,
Azevedo Paula,
Modesto Pamela,
Roscani Meliza,
Fernandes Ana,
Paiva Sergio,
Zornoff Leonardo,
Matsubara Luiz,
Okoshi Marina,
Minicucci Marcos
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb596
Subject(s) - cardiotoxicity , oxidative stress , superoxide dismutase , endocrinology , chemistry , catalase , glutathione peroxidase , medicine , doxorubicin , saline , pharmacology , toxicity , chemotherapy
Aim Evaluate pamidronate (Pam) effects in ventricular function, matrix metalloproteinase‐2 (MMP‐2) activity, oxidative stress, and myocardial energetic metabolism during acute doxorubicin (Dox)‐induced cardiotoxicity. Methods 64 Wistar rats were allocated in 4 groups: Control, Dox, Pam and Dox + Pam. Rats received Pam (3 mg/kg, IP) or saline. After 24 hours, rats received Dox (20 mg/kg, IP) or saline. Forty‐eight hours after Dox injection, rats were euthanized. Statistical analysis: two‐way ANOVA. Results Dox induced diastolic and systolic ventricular dysfunction and increased MMP‐2 activity. Dox increased myocardial oxidative stress (increased in lipid hydroperoxide, and decreased in catalase, superoxide dismutase and glutathione peroxidase myocardial levels) and impaired myocardial energetic metabolism (increased in phosphofructokinase and decreased in β‐hydroxyacyl dehydrogenase myocardial levels). Pam associated with Dox did not change ventricular function or MMP‐2 activity, but it decreased lipid hydroperoxide (p=0.042) and increased catalase (p<0.001) and superoxide dismutase levels (p<0.001). Also, Pam improved phosphofructokinase (p=0.021) and β‐hydroxyacyl dehydrogenase levels (p<0.001). Conclusion Pam attenuated acute Dox‐induced cardiotoxicity because it decreased oxidative stress and modulated myocardial energetic metabolism. Acknowledgement: PROPe‐UNESP and FAPESP.