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Effect of Gastric Bypass Surgery on Endothelial function and Heart Rate Variability
Author(s) -
Lee Kyuwan,
DeVallance Evan,
Grogg Kristen,
Mason Rebecca,
Hull Robert,
Rosati Kristen,
Tabone Lawrence,
Frisbee Jefferson,
Chantler Paul
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb568
Subject(s) - medicine , gastric bypass surgery , heart rate variability , arterial stiffness , cardiology , bypass surgery , peripheral , obesity , endothelial dysfunction , reactive hyperemia , heart rate , gastric bypass , autonomic function , endothelium , weight loss , surgery , blood pressure , artery , vasodilation
The obesity epidemic in the US has reached 155 million people. Obesity is associated with increased incidence of cardiovascular (CV) and metabolic diseases. The use of gastric bypass surgery has been shown to decrease excess body weight and reduce CV risk. Although, more than 100,000 procedures were performed during the past decade, it is unclear how it contributes to endothelial and autonomic function. The purpose of this study was to examine the outcomes of gastric bypass surgery on endothelial function and heart rate variability (HRV). We assessed 12 gastric bypass patient's peripheral arterial and endothelial function along with HRV using EndoPAT device, pre and 1 week post‐surgery. The mean of augmentation index (AI) was lower ( p <0.05) 1 week post‐surgery (1.7±8.0 to ‐7.2±4.1) with an increase in mean of AI pulse (178±12 to 193±46, p<0.05). LF/HF ratio was increased (1.03±0.26 to 1.34±0.28, p<0.05) after gastric bypass surgery suggesting that it may contribute to improved autonomic modulation of CV function. In contrast, no changes were found in endothelial function. These findings show that gastric bypass surgery improves the parasympathetic to sympathetic input on the heart and peripheral arterial stiffness despite no change in endothelial function.