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Concurrent Lung Pathology in Dogs with Chronic Liver Disease
Author(s) -
Montgomery Julia,
Montgomery James,
Simko Elemir,
Hendrick Steve
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb440
Subject(s) - medicine , cirrhosis , pathology , lung , chronic liver disease , liver disease , interstitial lung disease , liver biopsy , biopsy , gastroenterology
Remote lung injury is a frequent sequela of chronic liver disease, especially liver cirrhosis, in people. Anecdotal evidence of concurrent lung pathology in dogs with chronic liver disease warrants further investigation in this species. The objective was to perform a retrospective analysis of dogs diagnosed with cirrhotic and non‐cirrhotic chronic liver disease and determine if there is radiographic and/or histopathologic evidence of concurrent pulmonary pathology. Dogs were diagnosed with chronic liver disease based on history, clinical signs, clinicopathological abnormalities, diagnostic imaging, biopsy, and/or necropsy. Only dogs where liver disease was confirmed with diagnostic imaging, liver biopsy, and/or necropsy were included in the study (n=28). Evidence of concurrent lung pathology was based on radiographic and/or histopathologic findings. 23/28 dogs (82%) (95% CI: 63‐94%) had evidence of lung pathology. 18/28 dogs (64%) (95% CI: 44%‐81%) had an interstitial pattern on thoracic radiographs. A specific diagnosis of liver cirrhosis was not related to concurrent lung pathology (P=0.53) or an interstitial lung pattern (P=0.42). In conclusion, lung pathology was quite common (>80%) in dogs with liver disease. However, there was no clear relationship between liver cirrhosis and concurrent lung pathology or interstitial lung pattern in our group of dogs. Prospective research is needed to further evaluate dogs as an animal model for study of remote lung injury in chronic liver disease.