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Phosphorus supplementation recovers the blunted diet induced thermogenesis in overweight and obese subjects
Author(s) -
Bassil Maya,
Obeid Omar
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb372
Subject(s) - overweight , postprandial , medicine , endocrinology , thermogenesis , placebo , obesity , meal , insulin , alternative medicine , pathology
Diet induced thermogenesis (DIT) of obese subjects was reported to be blunted or lower than that of lean subjects (Ravussin & Swinburn, 1996). We have previously found that phosphorus (P) supplementation increases DIT of glucose solution in healthy lean subjects (Bassil et al , 2013) probably due to an increase in postprandial ATP production. A study was conducted to investigate whether P supplementation is able to stimulate DIT of overweight and obese subjects. DIT of glucose solution was measured with or without P in 12 overweight and obese subjects (4M, 8F; Age=22.4±1.2y; BMI= 30.3 ±0.9kg/m 2 ) in a double‐blind cross over design with 1 week washout period. After a 10‐h overnight fast, subjects drank a standardized 296mL solution containing 75g glucose, with P (500mg) or placebo pills. Oxygen consumption (VO 2 ) was measured every 30 min for 3 hours using an indirect calorimeter to derive energy expenditure. Baseline fasting resting metabolic rate (RMR) and VO 2 did not differ between the 2 experiments (p=0.4). In line with the literature, DIT of overweight and obese subjects was blunted with placebo, whereby VO 2 did not change from baseline after the consumption of glucose solution. Conversely, P supplementation was associated with a significant increase (p<0.05) in VO 2 during the first 90 min (320±17 mL/min) compared with baseline (297±10 mL/min) which was equivalent to a 10% increase in DIT from baseline. In conclusion, P supplementation recovers the blunted DIT in overweight and obese subjects. These results highlight the important role of P in energy balance in obesity. Further studies are warranted to elucidate the long term effects of P supplementation and to explore potential mechanisms of action.