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Resistance Training and Mitochondrial Metabolism
Author(s) -
Flack Kyle,
Davy Kevin,
Hulver Matthew,
Frisard Madlyn,
Anderson Angela,
Boutagy Nabil,
Savla Jyoti,
Winett Richard,
Davy Brenda
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb363
Subject(s) - skeletal muscle , citrate synthase , medicine , endocrinology , oxidative phosphorylation , pyruvate dehydrogenase complex , metabolism , resistance training , chemistry , exercise physiology , enzyme , biochemistry
Objective To determine if resistance exercise training improves skeletal muscle substrate oxidative capacity in older adults. Background A decline in skeletal muscle oxidative capacity occurs with aging. Aerobic exercise increases skeletal muscle's ability to oxidize multiple substrates. The role resistance exercise training (RT) has on skeletal muscle substrate oxidative capacity is unclear. Methods 19 males aged 蠅60 were randomized (RT=11, sedentary control=8). RT included 7 machine exercises, 1 set to failure ~8‐12 reps, 3x/week for 12 weeks. Muscle biopsies were obtained from the v. lateralis at baseline and 12 weeks. Palmitate and pyruvate oxidation, enzyme activity of 3‐hydroxyacyl‐CoA dehydrogenase (β‐HAD) and citrate synthase (CS) were assessed from muscle homogenates, strength from 3‐rep maximum (3RM). Results 3RM improved 75 and 74 % (P<0.01) for chest and leg press with RT. No change in total fatty acid (1.23±4.76 vs. 0.64±6.74 nm CO 2 /hr) or pyruvate oxidation (150.11 ± 291.76 vs. 53.28±302.44 nm CO 2 /mg/hr, P>0.05) in RT vs control respectively. β‐HAD increased (6.89±8.94 ng/mg/min, P<0.05) but not CS with RT. Conclusions These results suggest that 12 weeks of RT does not change skeletal muscle oxidative capacity in older men.