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Effects of Valerian/Hop Mixture on Sleep Quality in Vertebrate and Invertebrate Model
Author(s) -
Jo Kyungae,
Hong KiBae,
Park Yooheon,
Suh Hyung Joo
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb342
Subject(s) - valerian , insomnia , medicine , sleep onset latency , pharmacology , biology , traditional medicine , sleep onset
Insomnia, or sleep disorder, is a common complaint in the general population and the etiologies of insomnia are complex. Treatments for insomnia can be divided into pharmacological agent and non‐ pharmacological remedies, and the most of pharmacological treatments those prescribed for insomnia bring some risks such as overdose, tolerance and addiction. Available evidence suggests that modulation of sleep can be controlled by non‐pharmacological treatments such as bioactive molecules, natural substances, precursors for serotonin and melatonin. Extracts of valerian ( Valeriana officinialis ) and hop ( Humulus lupulus ) are the most frequently used natural treatments of anxiety, depression and insomnia. The aim of this study was to investigate the effect of valerian/hop mixture in invertebrate model ( Drosophila melanogaster ) and vertebrate model ( Rattus norvegicus ). Valerian and various hops (Cascade, Haallertau, Saaz) used for the study was prepared as 70% ethanol extract. Drosophila was used to test sleep‐wake behavior and dose‐response. In addition, vertebrate model was used for electroencephalogram (EEG) analysis to acquire sleep quality, duration and latency. The results provided the evidences that valerian/hop mixture can be a plausible remedy for sleep disorder.