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Age and Sex Analysis on the Relationship between Serum 25‐Hydroxyvitamin D and Hypertension in General Korean Population
Author(s) -
Kim Dasom,
Kim Jihye
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb329
Subject(s) - medicine , confounding , quartile , population , vitamin d and neurology , cross sectional study , gastroenterology , endocrinology , confidence interval , environmental health , pathology
Background Previous studies have suggested that serum 25‐hydroxyvitamin D [25(OH)D] is associated with hypertension. However, it has not been examined the age difference on the relation between serum 25(OH)D and the risk of hypertension. Objective The present study examined the relationship between serum 25(OH)D and the risk of hypertension by age in general South Korean populations with considering potential risk factors for hypertension. Methods We conducted a population‐based, cross‐sectional study.20,440 adults aged 19 years or over that participated in 2009 to 2012 Korean National Health and Nutrition ExaminationSurveys were selected for the present study. Hypertension was defined as SBP 蠅140 mmHg, or DBP蠅90 mmHg, or current use of anti‐hypertensive medication. Results We found that serum 25(OH)D levels are inversely associated with the risk of hypertension in young and middle‐aged adults, but not in elderly. In young and middle‐aged adults, the adjusted ORs for hypertension tended to decrease according to the quartiles of serum 25(OH)D after adjustment for potential confounders significantly only in women (OR=0.73, 95% CI=0.58‐0.91, P for trend =0.0345). ). Although the adjusted ORs for hypertension showed the tendency to decrease with increasing serum 25(OH)Dconcentration, the association was not significant. There was no association between serum 25(OH)D concentration and the risk of hypertension in elderly subjects. Conclusion Higher serum 25(OH)D level was strongly associated with a lower risk of hypertension in young and middle‐aged Korean women, not in elderly.