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Comparison of Phenolic Acids on Alleviating High‐Fat and High‐Fructose Diet‐Induced Metabolic Dysfunctions
Author(s) -
Wang Ou,
Zhang Di,
Cheng Qian,
Liu Jia,
Guo Xiaoxuan,
Ji Baoping
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb324
Subject(s) - gallic acid , chemistry , protocatechuic acid , fructose , caffeic acid , chlorogenic acid , antioxidant , adiponectin , polyphenol , food science , biochemistry , ellagic acid , insulin resistance , medicine , obesity
Phenolic acids, one of the major kinds of polyphenols, widely present in edible plants and have many health benefits. This study compares the alleviation effects of six kinds of common phenolic acids on high‐fat and high‐fructose diet (HFFD)‐induced metabolic dysfunctions. Male Sprague‐Dawley rats were fed on normal diet, HFFD, and HFFD supplemented with equimolar of phenolic acids (2.6 mmol/kg diet) for 13 weeks. Lipid and glucose metabolism, insulin resistance (IR) index, hepatic functions, inflammation levels, serum antioxidant capacity were analyzed at the end of the experiment. Results showed that gallic acid and ρ‐coumaric acid treatments showed potential better effects in lowering liver index and inhibiting hepatic fat accumulation, but gallic acid failed to improve serum antioxidant capacity. Caffeic acid treatment could not inhibit the HFFD‐induced body weight gain and liver index increase significantly, but it ranked highly among all the groups in markedly lowering serum lipids levels, normalizing hepatic functions, enhancing antioxidant capacity and improving IR. Chlorogenic acid and ellagic acid exhibited significant effects in lowering C‐reaction protein and interleukin‐6 levels and increasing adiponectin concentration, which were better than the other groups. Protocatechuic acid was the least effective one among these groups as less significant effect was observed. The results suggest that under the same applied dosage, phenolic acids alleviate different deleterious effects of HFFD.