Daily Consumption of Fructose for 15 Weeks Leads to Metabolic Disorders and Impaired Renal Function without Cause Obesity

To evaluate the effect of daily consumption of fructose on body weight and urine parameters indicative of kidney damage. Male Wistar rats were divided to receive standard diet + water (C group, n=24) or standard diet + frutose in drinking water (30%) for 15 weeks. At the end of this period, we assessed the animals' weight (g), calorie intake (kcal), plasm glucose (glu) and triglycerides (TG)‐ (mg/dL), glucose, albumin (alb) and creatinine (creat) urinary (mg/dL). The groups were compared by Student t ‐test and Mann‐Whitney and the data are expressed as mean ± standard deviation or median, 1st ‐ 3rd quartiles.There was no difference in weight (C= 388.22; 341.11‐ 425.39 x F= 384.44; 331.89‐ 419.50, p= 0.77) and caloric intake (C= 280.29; 255.66‐ 334.45 x F=297.86; 264.27‐ 357.21; p= 0.17) between the groups. There was increased glu (C= 131.51 ± 16.49 x F= 142.60 ± 20.54, p= 0.04) e TG (C=87.72; 68.57‐ 106.40 x F= 108.66; 86.796‐ 136.27, p= 0.006) in animals F compared to C. In urine, F animals showed an increased alb (C= 0.07; 0.05‐ 0.10 x F= 0.09; 0.07‐ 0.13, p= 0.04), glu (C= 7.08 ± 4.88 x F= 11.51 ± 6.35, p= 0.013) and creat (C= 138.32; 85.07‐ 179.34 x F= 189.04; 146.70‐ 250.69. p= 0.002). Even without causing obesity, the daily consumption of fructose for 15 weeks leads to alterations in glucose, triglycerides and markers of renal function, which is a health risk.