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Daily Consumption of Fructose for 15 Weeks Leads to Metabolic Disorders and Impaired Renal Function without Cause Obesity
Author(s) -
Francisqueti Fabiane,
Betti Isabella,
Minatel Igor,
Ferron Artur,
Santos Klinsmann,
Nascimento Andre,
Silva Vanessa,
Correa Camila
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb302
Subject(s) - medicine , endocrinology , creatinine , chemistry , renal function , urine , fructose , zoology , biology , biochemistry
To evaluate the effect of daily consumption of fructose on body weight and urine parameters indicative of kidney damage. Male Wistar rats were divided to receive standard diet + water (C group, n=24) or standard diet + frutose in drinking water (30%) for 15 weeks. At the end of this period, we assessed the animals' weight (g), calorie intake (kcal), plasm glucose (glu) and triglycerides (TG)‐ (mg/dL), glucose, albumin (alb) and creatinine (creat) urinary (mg/dL). The groups were compared by Student t ‐test and Mann‐Whitney and the data are expressed as mean ± standard deviation or median, 1st ‐ 3rd quartiles.There was no difference in weight (C= 388.22; 341.11‐ 425.39 x F= 384.44; 331.89‐ 419.50, p= 0.77) and caloric intake (C= 280.29; 255.66‐ 334.45 x F=297.86; 264.27‐ 357.21; p= 0.17) between the groups. There was increased glu (C= 131.51 ± 16.49 x F= 142.60 ± 20.54, p= 0.04) e TG (C=87.72; 68.57‐ 106.40 x F= 108.66; 86.796‐ 136.27, p= 0.006) in animals F compared to C. In urine, F animals showed an increased alb (C= 0.07; 0.05‐ 0.10 x F= 0.09; 0.07‐ 0.13, p= 0.04), glu (C= 7.08 ± 4.88 x F= 11.51 ± 6.35, p= 0.013) and creat (C= 138.32; 85.07‐ 179.34 x F= 189.04; 146.70‐ 250.69. p= 0.002). Even without causing obesity, the daily consumption of fructose for 15 weeks leads to alterations in glucose, triglycerides and markers of renal function, which is a health risk.