Premium
Intake of Fish and n‐3 Polyunsaturated Fatty Acids and Risk of Cognitive Deficit From Mild Impairment to Severe Disease: Dose‐response Meta‐analysis of 24 Independent Cohort Studies
Author(s) -
Zhang Yu,
Jiao Jingjing
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb286
Subject(s) - polyunsaturated fatty acid , medicine , meta analysis , dementia , cognitive decline , relative risk , fish oil , cohort , population , effects of sleep deprivation on cognitive performance , cohort study , cognition , disease , physiology , environmental health , confidence interval , biology , fish <actinopterygii> , fatty acid , psychiatry , biochemistry , fishery
Objective To conduct a systematic review and meta‐analysis of the intake of fish and n‐3 polyunsaturated fatty acids (PUFA) and the risk of cognitive deficit. Methods The Pubmed and Embase databases were searched. Studies reporting risk estimates for cognitive decline, mild cognitive impairment (MCI), dementia, Parkinson's disease (PD), or Alzheimer's disease (AD) from fish, total PUFA, total n‐3 PUFA, or at least one n‐3 PUFA were included. The summary relative risks (RR) were estimated by categorical and dose‐response analysis. Results Twenty‐four cohort studies (29 publications) with a total population of 218 145 were included. The dietary intake of fish was inversely associated with the risk of cognitive deficit (RR: 0.82, 95% CI: 0.76, 0.88). Additionally, a 20 g/day or 1 serving/week increment of daily fish was associated with 11% and 9% lower risks of cognitive deficit, respectively. Two types of marine n‐3 PUFA were significantly associated with the risk of cognitive deficit (EPA: 0.90, 95% CI: 0.82, 0.98; DHA: 0.92, 95% CI: 0.84, 0.99), but their associations did not appear to be significant in a dose‐response effect. The plant n‐3 PUFA ALA was not categorically associated with the risk of cognitive deficit, but a 0.1 g/day increment of ALA intake led to a 2% reduction of the risk in the dose‐response meta‐analysis. Conclusions This meta‐analysis suggested a protective effect of fish consumption on cognitive deficit. Marine‐derived n‐3 PUFA was associated with the risk of cognitive deficit, but not in a dose‐response way.