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Effects of an Exercise and Diet‐Induced Weight Loss Program on Resistin and Visfatin in Sedentary Obese Women
Author(s) -
Khanna D,
Galvan E,
Baetge C,
Levers K,
Simbo S,
Byrd M,
Jung P,
Koozehchian M,
Rasmussen C,
Greenwood M,
Kreider R
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb254
Subject(s) - resistin , medicine , leptin , endocrinology , obesity , weight loss , adipose tissue , insulin resistance , adipokine , insulin , inflammation
Resistin and visfatin are secreted by adipose tissue and potential regulators of inflammation and insulin sensitivity. This study examined the effects of exercise and diet‐induced weight loss on resistin, visfatin and other adiposity and inflammatory markers. 26 sedentary obese women were randomly assigned into a control (C) or an exercise (E) group that involved circuit resistance‐exercise (4 d/wk) with walking (10,000 steps/d, 3 d/wk) while consuming 1,200 kcal/day for 1‐wk and 1,500 kcal/d diet for 11 wks consisting of 45:30 % PRO:CHO. Baseline and post‐training DEXA body composition and fasting blood samples were obtained and analyzed by MANOVA and Pearson correlation analysis. Data are presented as mean±SD changes from baseline. Participants in the E group lost more weight (E: ‐13.0±8.9; C: ‐1.4±3.1 lbs, p=0.001) and fat (E: ‐5.1±4.5; C:‐0.4±1.5 kg, p=0.001). Significant differences were seen between groups in leptin (E: ‐19.8±21.9; C: 4.5±16 ng/ml, p=0.003) while visfatin (E: ‐0.09±15.4; C: 89.3±177 ng/ml, p=0.095), IL‐6 (E: ‐38.9±46; C:264.4±597 %, p=0.093), TNF‐α (E: 1.57±28; C: 96.9±186 %, p=0.093), and insulin (E: ‐8.5±14.9; C:0.12±7.7 uIU/ml, p=0.070) tended to differ between groups and no differences were seen in resistin (E: 5.7±126; C: ‐62.3±162 ng/ml, p=0.25) or glucose (E: ‐3.8±19.8; C:‐2.8±6.9 %, p=0.87). Significant correlations were seen between changes in resistin and TNF‐α (r = ‐0.49) while changes in visfatin correlated with changes in leptin (r=0.51) and IL6 (r=0.91). These findings indicate that exercise has beneficial effects on weight loss and body composition and this may adiposity and inflammatory markers.