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Assessment of Serum Levels of Dehydroepiandrosterone Sulfate (DHEAS) and Estriol (E3) in the 2 nd and 3rd Trimesters of Pregnancy, in Some Selected Obstetrics and Gynecological Specialist Hospitals in Port Harcourt: A Measure of Fetal Well‐being
Author(s) -
Anacletus Frank,
Onwuka Adaora,
Ogwe Geraldine
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb100
Subject(s) - dehydroepiandrosterone sulfate , estriol , medicine , obstetrics , dehydroepiandrosterone , pregnancy , gynecology , port harcourt , endocrinology , androgen , hormone , biology , socioeconomics , sociology , genetics
The serum levels of dehydroepiandrosterone sulfate (DHEAS) and Estriol (E3) was investigated in fifty (50) pregnant women in their second and third trimesters of pregnancy in some selected obstetrics and gynecological specialist hospitals in Port Harcourt, as a relevant measure of fetal well‐being. As a routine, the consent of the women was obtained for the test to be performed both for medical and academic purpose. 4‐5ml of blood was collected individually into a labeled lithium heparin bottle, and stored at 4 0 C for up to 24 hours and at – 10 0 C for those samples to be analyzed at a later date. The investigation was carried out using enzyme‐linked immunosorbent assay (ELISA) method with the use of an automated micro plate reader. The data obtained was compared with the standard reference values for DHEAS and E3. The result obtained showed a significant steady increase in dehydroepiandrosterone sulfate as well as that of Estriol when compared to reference values, as the trimester progresses. There was also an observed decrease in DHEAS and E3 as age of the patients increases. Slight increases in the levels of DHEAS and E3 are used to monitor the progress of the pregnancy and they also indicate fetal well‐being