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Aerobic Training Prevents Impairment in Vascular Reactivity in Rats Under High Risk of Metabolic Syndrome
Author(s) -
Medeiros Renata,
BentoBernardes Thais,
Gaique Thaiane,
Britto Fernanda Carla,
Motta Nádia Alice,
Oliveira Karen,
Nóbrega Antonio Claudio
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.994.26
Subject(s) - enos , aerobic exercise , medicine , vasodilation , endocrinology , nitric oxide , metabolic syndrome , phenylephrine , fructose , blood pressure , nitric oxide synthase , diabetes mellitus , chemistry , biochemistry
It is still unknown the whole mechanisms through which the aerobic training could prevent the development of metabolic syndrome. So the aim of this study was to investigate the vascular mechanism of aerobic training on vascular reactivity of rats under high risk of metabolic syndrome. Wistar rats (n=7/group), males, adults, were divided in Control group (C; drinking water), Fructose group (F; water with 10% fructose), both for 10 weeks; Control Training group (CT) and Fructose Training group (FT), both same as C and F groups, respectively, adding moderated aerobic training on a treadmill (04 times/week) in the last 8 weeks. There were no differences in body mass gain, caloric intake, glycaemia, blood pressure and heart rate between groups. Triglycerides, insulin and isoprostane were higher only in F group and was similar between FT, CT, and C groups. Nitric oxide was higher in trained groups when compared to sedentary groups. In addition, the F group exhibited increased vasoconstrictory reactivity to phenylephrine when compared to C and FT. The F group also presented an impaired endothelial vasodilator response to acetylcholine compared to C and FT vasodilatory response was similar to C and CT groups. F group had lower eNOS expression when compared to C group. The groups that trained had higher values when compared to their sedentary controls; there was no difference between CT and FT groups. In relation to eNOS (phospho S1177) it was observed that the trained groups had higher values when compared to sedentary groups. In conclusion aerobic exercise prevents damage in vascular reactivity, increases eNOS and peNOS expression in this model.