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Changes in Arterial Stiffness and Blood Pressure during Various Vascular Reactivity Tests
Author(s) -
Lim Jisok,
Pearman Miriam,
alkatan Mohammed,
Machin Daniel,
Park Wonil,
Tanaka Hirofumi
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.994.23
Subject(s) - arterial stiffness , blood pressure , cold pressor test , cardiology , medicine , pulse wave velocity , isometric exercise , heart rate
Increased arterial stiffness is an independent marker of cardiovascular risk. However, some investigators have questioned the utility of arterial stiffness above and beyond the traditional blood pressure (BP) measurement as the change in arterial stiffness is often accompanied by corresponding changes in BP. Although the associations between chronic levels of arterial stiffness and BP have been fairly well studied, it is unclear if and how much arterial stiffness is influenced by acute BP changes. PURPOSE To determine the magnitude of BP‐dependence of arterial stiffness during acute BP perturbations. METHODS Thirty apparently healthy subjects (46±4 years; 17 males) were studied. BP perturbations, including head‐up tilt, head‐down tilt, mental stress, isometric handgrip exercise, and cold pressor test were used to encompass blood pressure changes induced by physical, mental, and/or physiological stimuli. Arterial stiffness was measured with carotid‐femoral pulse wave velocity (PWV). RESULTS PWV was significantly associated with mean BP at rest (r=0.42). Mean BP was significantly changed during each perturbation, and changes ranged from △5±4 to △22±4 mmHg. Changes in mean BP and PWV were significantly correlated during mental stress (r=0.44), handgrip exercise (r=0.55), and cold pressor test (r=0.39). Significant associations were not found during head‐up tilt and head‐down tilt.CONCLUSION This study demonstrates that changes in arterial stiffness, as assessed by PWV, are significantly associated with acute BP changes during some BP perturbations but BP‐dependence of arterial stiffness is not observed in all perturbations. Supported by Fukuda Denshi.