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Actions of Angiotensin II at the OVLT and Voluntary Alcohol Ingestion
Author(s) -
Collister John,
Drebes Donna,
Nahey David
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.988.3
Subject(s) - subfornical organ , angiotensin ii , lamina terminalis , medicine , endocrinology , circumventricular organs , blood pressure , alcohol , renin–angiotensin system , lesion , osmoreceptor , saline , thirst , hypothalamus , chemistry , surgery , biochemistry
Alcohol abuse leads to morbidity and mortality related to a variety of causes. While the hormone angiotensin II (AngII) is known to regulate sodium and water balance as well as blood pressure, there is convincing evidence that AngII is involved with voluntary alcohol consumption. Previous studies reported decreases in voluntary alcohol intake after AngII treatment that was blocked in rats with lesion of the subfornical organ (SFO), a circumventricular organ (CVO) outside the blood brain barrier accessible by circulating AngII. Others have reported that administration of central AngII actually increases alcohol intake. Our lab has reported that many chronic effects of AngII are mediated via the organum vasculosum of the lamina terminalis (OVLT), another CVO, in addition to the SFO. The AIM of the present study was to demonstrate effects of peripherally administered AngII at the OVLT on alcohol consumption. We tested the hypothesis that chronic AngII administration induces increased alcohol consumption via the OVLT. Rats were subjected to OVLT (n=4) or sham (n=4) lesion and implanted with IV catheters and aortic telemetric transmitters for recording of arterial pressure. A 4.0% NaCl diet, distilled water and 6.0% ethanol were provided ad libitum. After a 3 day control period of saline infusion, rats were intravenously infused with AngII (10 ng/kg/min) for ten days. Baseline ethanol intake was similar between OVLT lesioned (5.8±2.5 ml) and sham (4.8±1.6 ml) rats. By day 5 of AngII treatment, while alcohol intake had increased in both groups compared to control levels, this effect was attenuated in OVLT lesioned rats (9.3±3.7 ml/day) compared to sham operated rats (16.6±6.0 ml/day). These data support the hypothesis that the OVLT mediates ethanol consummatory effects of chronically administered AngII.