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Relationship between hippocampal CA1 neuronal and sympathetic nerve activity during fear conditioning in rats
Author(s) -
Yoshimoto Misa,
Kanayama Misaki,
Miki Kenju
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.986.6
Subject(s) - hippocampal formation , premovement neuronal activity , neuroscience , fear conditioning , hippocampus , conditioning , medicine , psychology , amygdala , statistics , mathematics
The hippocampus has been implicated in the emotional responses of sympathetic nerve activity (SNA) to fear. However, there is a lack of direct evidence of the changes in hippocampal neuronal activity and SNA and on the functional relationships between these activities during the fear response. The aim of the present study was to measure the relationship between hippocampal neuronal activity and SNA during fear conditioning. Male Wistar rats were chronically implanted with multiple electrodes to monitor hippocampal CA1 neuronal activity, and bipolar electrodes to monitor renal SNA (RSNA) and lumbar SNA (LSNA). Electroencephalography was performed. Each rat was given a 5‐s tone terminating with a 1‐s, 5‐mA foot shock twice a day over 3 days. Hippocampal CA1 neuronal activity, RSNA, and LSNA were measured simultaneously during the quiet awake state in the rat's own cage. Heart rate decreased during the 3‐day fear conditioning. Hippocampal CA1 neuronal activity and RSNA increased, while LSNA decreased during the 3‐day fear conditioning. These data suggest that there is a positive neuronal coupling between hippocampal neural activity and RSNA during fear conditioning in rats. JSPS Grant.