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Impact of Chronic Salt Load on Mean Arterial Pressure in Female Growth Restricted Rats at One Year of Age
Author(s) -
Brown Andrew,
Intapad Suttira,
Alexander Barbara
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.966.8
Subject(s) - medicine , endocrinology , offspring , blood pressure , menopause , mean arterial pressure , senescence , estrous cycle , pregnancy , biology , heart rate , genetics
Salt sensitivity is an risk factor for cardiovascular (CV) disease and the prevalence of salt sensitivity increases after menopause. LBW women exhibit early menopause associated with increased adiposity and enhanced CV risk including salt sensitivity. Our laboratory utilizes a rat model of intrauterine growth‐restriction (IUGR) induced via placental insufficiency. In this model female IUGR offspring develop persistent estrous by one year of age indicative of early reproductive senescence. Thus, the goal of this study was to test the hypothesis that female IUGR rats develop salt sensitivity in association with early reproductive aging. Female IUGR rats were placed on a regular rodent chow (RC) diet (0.4% salt) or a high Na+Cl2 (8%) diet for three weeks. Rats underwent weekly assessment prior to and during chronic salt load of: food and water intake and urine output via 24 hour metabolic studies, total fat and lean mass using Echo MRI, and body weight. Mean arterial pressure (MAP) was measured in conscious, chronically instrumented rats at the end of the 3 week protocol. Birth weight was significantly reduced in IUGR pups versus control (5.1±0.1 vs. 5.8±0.1 grams, P<0.05). Chronic salt load did not significantly alter MAP in female IUGR or control at one year of age (IUGR: 134±4 vs. 138±3 and Control: 130±3 vs. 128±3; RC vs. High Salt). 24 hour sodium excretion also did not differ (RC: 16±3 vs. 19±2; High Salt: 202±15 vs. 172±14 mmol, IUGR vs. Control, respectively). Thus, these data indicate that female IUGR do not significantly increase their blood pressure in response to chronic salt load indicating that they are not salt‐sensitive. NIH: HL074927, HL51971, P20GM104357, AHA GRNT19900004