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Evaluation of Cardiac ACE in Rats with Experimental Model of Metabolic Syndrome Induced by Fructose Intake
Author(s) -
Souza Marina,
Araujo Iara,
Americo Anna,
Muller Cynthia,
Fiorino Patricia,
Farah Vera
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.957.10
Subject(s) - fructose , medicine , hyperinsulinemia , endocrinology , metabolic syndrome , blood pressure , diabetes mellitus , lipid profile , type 2 diabetes , sugar , ingestion , blood sugar , obesity , chemistry , insulin resistance , biochemistry
The high consuming of fructose sugar is a concern for public health, since factors such as cardiovascular diseases, obesity, type‐2 diabetes and metabolic syndrome are related to this new food habits. The Renin‐Angiotensin System (RAS), an endocrine system responsible for regulating blood pressure, is widely studied since its components are sensitive to hyperglycemia and hyperinsulinemia, events that occur in the diet rich in fructose. The aim of the study was to evaluate an important marker of RAS, the angiotensin‐converting enzyme (ACE), in the heart of animals treated with fructose. Weaned Wistar rats were divided into control group (CG) and fructose group (FG, 10% in drinking water) and treated for 8 weeks. FG showed changes in lipid profile when compared to GC, with increased triglycerides (CG=39±3 vs FG=49±2*) and LDL (CG=48±2 vs FG=50±3*) and decreased HDL (CG=35±2 vs FG=24±1*). FG showed lower glucose tolerance than CG on GTT (CG=113±4 vs FG=169±2*), featuring the experimental model. Mean arterial pressure was increased in FG (CG=110±1 vs FG=125±1*)and quantification of ACE showed a significant increase in CG vs. FG (p<0.05), suggesting the increased activation of the RAS in GF than in GC, concluding that chronic ingestion of fructose may induce harmful and important metabolic changes that can lead to serious diseases, such as hypertension and type 2 diabetes. (*p<0,05 vs CG). Support by: PIBIC/Mackenzie