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Cerebrolysin effects on cardiovascular hemodynamic parameters in Sprague Dawley rats with chronic hyperglycemia induced by streptozotocin
Author(s) -
Zurita Enedina,
De Jesús Luis,
Suarez Jorge,
Gomez Ma. de Jesus
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.952.2
Subject(s) - medicine , cerebrolysin , diabetes mellitus , hemodynamics , endocrinology , heart rate , streptozotocin , blood pressure , saline , anesthesia
Autonomic denervation is a late complication of diabetes mellitus and is considered a cause of different cardiovascular disorders. In this study we evaluated the effect of Cerebrolysin (CBL) a neurotrophic factor, on cardiovascular hemodynamic parameters in rats with chronic hyperglycemia. Male Sprague Dawley rats were administered with streptozotocin (single dose, 60mg/Kg,ip). Hyperglycemic and normoglycemic rats were administered during 8 weeks with vehicle (saline 0.9 %) or Cerebrolysin (2ml/Kg/day, ip), at 60 days, after the induction of hyperglycemia. At the end, different parameters were measured in conscious rats: body weight (BW), heart rate (HR), heart rate variability (HRV), systolic arterial blood pressure (SABP), and blood glucose (BG). Heart weight (HW) and the ratio HW/BW were obtained after euthanized rats. The results shown that in the hyperglycemic rats the administration of CBL produce an increase in BW and HW, HR and HRV and a decreases in SABP as compared with hyperglycemic vehicle rats (BW 315±1 vs. 258±4), HW 1.4±0.07 vs. 1.1±0.05), ratio HW/BW 0.47±0.03 vs. 0.31±0.05), HR 322±8 vs. 278±1 beat/min), SABP 168±12 vs. 145±9 mmHg) (p< 0.001 for all comparison). The results suggest that the neurotrophic factor CBL, could improve the cardiovascular parameters in rats with chronic hyperglycemia and could be considered and adjacent treatment to patients with diabetes mellitus.