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Inactivation of a Potassium Channel
Author(s) -
McDermott Ann,
Bhate Manasi,
Wyle Benjamin,
Xu Yunyao
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.95.2
Subject(s) - potassium channel , potassium , selectivity , chemistry , mutant , biophysics , voltage gated potassium channel , ion channel , membrane , ion , membrane potential , biochemistry , biology , organic chemistry , gene , catalysis , receptor
Ion binding in a potassium ion channel is studied, yielding insights into inactivation. At high potassium the selectivity filter is in a conductive form, and at low potassium it collapses into a long‐lived nonconductive structure with reduced ion occupancy. Solid state NMR methods are applied to full length wild type channel in membrane bilayers, and to the inactivation‐less mutant E71A. We test the hypothesis that a universal important channel‐inactivation process has as its central step the evacuation of ions from the selectivity filter.