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The Inverse Proportionality Of Weight And Blood Glucose In Diabetic Wister Rat
Author(s) -
Otobo Tarimobo,
TarimoboOtobo Rugina,
Eshiet Idara
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.944.2
Subject(s) - medicine , endocrinology , streptozotocin , diabetes mellitus , body weight
Blood glucose haemostasis is pivotal in cellular metabolism, hence dysfunctional glucose regulation as seen in diabetes mellitus (DM) has profound negative metabolic consequences evident by the sequela associated with DM. Body habitus as a risk factor for DM and subsequent use of weight control measures in the management of this condition further highlights the casual relationship of overweight and DM. Although these relationship in clinical scenario is direct, physiological mechanism underlying the diseases seem to be in the reverse. The study was stratified into two groups, ten Control animals labelled Group C and ten experimental animals labelled group 5. The experimental group was selected out of the stable Wister rat pool post induction of DM with streptozotocin. Group 5 animals received 65mg/kg body weight of streptozotocin in sodium citrate buffer intraperitonealy. Group C animals received sodium citrate. Both groups were given animal feeds and water ad libitum. The blood glucose and weight where monitored for twelve weeks. Group 5 animals showed sustained hyperglycaemia (> 250mg/dl of blood glucose)within diabetic rang all through the experimental period, while their body weight reduced despite adequate feeding. Conversely, group C animals were nomoglycemic with an increase in body weight as the experiment progressed.The inverse relationship between body weight and hyperglycaemia is due to deranged glucose haemostasis and reduced cellular availability of glucose despite the presence of adequate energy source.