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The Effect of Pentadecapeptide BPC 157 on System Circulation and Thrombogenesis after Ligation of Vena Cava Inferior
Author(s) -
Vukojevic Jaksa,
Siroglavic Marko,
Kasnik Katarina,
Kralj Tamara,
Stancic Duje,
Drmic Domagoj,
Seiwerth Sven,
Sikiric Predrag
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.941.6
Subject(s) - inferior vena cava , medicine , ligation , abdominal aorta , aorta , saline , blood pressure , vena cava , central venous pressure , anesthesia , cardiology , heart rate
In this study we analyzed the effect of pentadecapeptide BPC 157 on the system circulation and thrombogenesis after ligation of vena cava inferior. We used female Wistar rats (200g) which underwent vena cava inferior ligation just above the right vena ovarica. Immediately after, controls received 1 ml of saline bath and the BPC 157 rats received 1 ml of BPC 157 (10 µg/kg) bath. The thrombi from the vein were evaluated macroscopically after extraction and the pressure in the abdominal aorta and vena cava was assessed after 1h and 24h. Control group at 1h had the thrombi lenght of 0.83±0.15 cm and the thrombi mass of 0.04±0.01g, and the control group at 24h had length of 1.60 ± 0.43 cm and mass of 0.074 ± 0.006 g, with blood pressure in abdominal aorta of 70.50 ± 2.12 mmHg after 24h and 72.4± 3.1 mmHg after 1h, while the pressure in vena cava inferior was 27± 1.2 mmHg after 1h and after 24h 26.3± 1.4 mmHg. BPC 157 treated group at 1h had the thrombi lenght of 0.4± 0.05cm and the mass of 0.01± 0.004 g, and the 24h BPC 157 group had length of 0.78 ± 0.07cm and mass of 0.032 ± 0.003g, with pressure in abdominal aorta of 98.0 ± 1.40 after 1h and after 24h it was 96.5± 1.8 mmHg, while the pressure in the vena cava inferior was 13± 1.5 mmHg after 1h, and after 24h 15± 0.8 mmHg. As conclusion, this study has shown significant beneficial effect of pentadecapeptide BPC 157 on system circulation and decrease both in thrombi size as well as blood pressure in vena cava inferior. Supported by Grant 108‐1083570‐3635, Croatia.