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CO‐ULTRAMICRONIZED PEALUT: A NEW THERAPEUTIC TREATMENT IN AUTISM SPECTRUM DISORDER
Author(s) -
Crupi Rosalia,
impellizzeri Daniela,
Bruschetta Giuseppe,
Cordaro Marika,
Esposito Emanuela,
Cuzzocrea Salvatore
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.931.12
Subject(s) - neurogenesis , neuroprotection , neuroplasticity , neuroscience , palmitoylethanolamide , medicine , autism , neuroinflammation , cerebrolysin , inflammation , psychology , psychiatry , antagonist , receptor , cannabinoid receptor
Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by neurological deficits, especially as related to cognitive function. Brain inflammation can be a key element in the pathogenesis of neuropsychiatric disorders, such as ASD. N‐palmitoylethanolamide (PEA) is a parent molecule of ALIAmides, known for its anti‐inflammatory, analgesic and neuroprotective properties. Flavonoids, such as luteolin, possess neuroprotective actions in central nervous pathophysiological conditions. Association of PEA with Luteolin (co‐ultra PEALut) displays neuroprotective and anti‐inflammatory actions in CNS pathologies which are superior when compared to each molecule alone. Our goal was to evaluate the effects evoked by PEALut in the management of inflammatory events associated with ASD using established experimental model. A multidisciplinary approach was employed to study: behavioral, neuroinflammatory, neurogenesis and neuroplasticity alterations. On P14, C57BL/6 mice were injected with 400 mg/kg sodium valproate. Two different set of experiments were conducted. In the first, on P15 mice were administered with PEALut and on P30 the behavioral and neuroinflammatory studies were assessed. In the second, at P120, mice started treatment with PEALut (2 weeks) and then were sacrified for neurogenesis and neuroplasticity investigations. Our study showed that PEALut ameliorated aggressive behavior and improved spatial learning memory in the autistic mice. Moreover PEALut increases neurogenesis and neuroplasticity in mice hippocampus.