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Network‐based Characterization of Inflammation Biomarkers, Phytochemicals and Disease
Author(s) -
Kamanu Frederick,
Zirkler Estelle,
Obin Martin,
Ordovas Jose,
Parnell Laurence,
Smith Caren
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.923.18
Subject(s) - inflammation , disease , phytochemical , medicine , bioinformatics , interactome , biology , traditional medicine , biochemistry , gene
Chronic inflammation is often a major contributor to the onset and progression of cardiometabolic dysfunction. Whether through effects on the inflammatory response system or independent of inflammation, plant‐derived polyphenols comprise a micro‐nutrient class important in cardiovascular disease and other cardiometabolic traits. Well‐known effects of these compounds include reducing blood glucose, acting as a diuretic, and raising HDL cholesterol. Using a computational approach, published phytochemicals and disease interaction information was mined from the literature and integrated with publicly available phytochemical data, including those relating specific phytochemicals to food items. The resulting federated database can be interrogated for the purpose of constructing molecular networks that depict relationships between diet, cardiometabolic traits, aging and inflammation. This nutrition‐inflammation interactome is a useful tool to understanding the diet‐disease‐inflammation axis and is also a vehicle for generating testable hypotheses in the laboratory setting. Funding: FY 15 Genomics account ‐ H020001 DA9519