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Dietary Strawberries Increase Glutathione in Obese Participants with Above Optimal Serum Lipids
Author(s) -
MORRIS STACY,
BETTS NANCY,
LYONS TIMOTHY,
BASU Arpita
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.922.7
Subject(s) - glutathione , antioxidant , catalase , medicine , calorie , flavonoid , antioxidant capacity , physiology , oxidative stress , chemistry , zoology , food science , biochemistry , biology , enzyme
Background Dietary flavonoid intake, especially berry flavonoids, has been associated with antioxidant functions and metal chelation in mechanistic studies. Purpose: We examined the hypothesis that freeze‐dried strawberries (FDS) improve antioxidant biomarkers in adults with abdominal adiposity and elevated serum lipids. Methods: In a randomized dose‐response controlled trial, 60 volunteers [5 men and 55 women; age: 49 ± 10 years; BMI: 36 ± 5 kg/m 2 (mean±SD)] were assigned to one of the following arms: low dose FDS (LD‐FDS) (25g/d), low dose control (LD‐C), high dose FDS (HD‐FDS) (50g/d), and high dose control (HD‐C) beverages for 12 weeks. Control beverages were matched for calories and total fiber. Serum levels of trace elements (copper, iron, selenium, zinc) and whole blood glutathione (GSH), and catalase activity were examined at screening (0 week) and after 12 weeks intervention. Results: At 12 weeks, glutathione levels were higher in HD‐FDS vs. LD‐FDS, as well as vs. HD‐C, and catalase activity was lower in HD‐FDS vs. baseline (all P<0.05). No differences were noted in serum trace elements following FDS intervention. Conclusions Dietary strawberries, especially at high doses may selectively modulate antioxidant biomarkers that influence risk factors of chronic diseases. These results need further confirmation in larger trials.