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Antioxidant and antiinflammatory properties of freeze‐dried cranberry powder in ovariectomized Rats
Author(s) -
Lee Kiuk,
Jung Hana,
Hwang Keum Taek,
Kwak HoKyung
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.922.20
Subject(s) - ovariectomized rat , placebo , pellet , antioxidant , chemistry , estrogen , endocrinology , medicine , cranberry juice , nitric oxide , zoology , biology , biochemistry , alternative medicine , urinary system , pathology
The aim of this study was to examine antioxidant and antiinflammatory effects of the freeze‐dried cranberry powder employing an ovariectomized rat model. Female Sprague‐Dawley rats were either ovariectomized or sham‐operated and divided into five groups: 1) ovariectomy (OVX) + placebo pellet + 2% cranberry diet (CB2); 2) OVX + placebo pellet + 5% cranberry diet (CB5); 3) OVX + estrogen pellet (60 days released, 17β‐estradiol) + control diet (ES); 4) OVX + placebo pellet + control diet (NC); and 5) sham‐operated + control diet (sham). After 8 weeks of experimental period, serum malondialdehydes were tended to be lower in CB2 and CB5 than NC and ES. In addition, CB5 showed 14 and 30% lower mean serum nitric oxide than NC and ES, respectively (P>0.05). Mean levels of oxidized low density lipoproteins were decreased by 2‐4% with cranberry powder (P>0.05), while a significant reduction was observed in ES (P<0.05). In addition, mean C‐reactive protein was significantly lower in ES than other groups, but was not altered by diets with cranberry powder. However, cranberry powder decreased serum IL‐10, IL‐6 and IL‐1α (P>0.05) in a dose dependent manner.