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A Lycium Chinense Beverage Alleviated Inflammation in Overweight Subjects with High LDL Cholesterol Level: a Double‐Blinded, Randomized, Placebo‐Controlled Study
Author(s) -
Ahn Youngsook,
Lee You jin,
Lim Yeni,
Kwon Oran
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.922.2
Subject(s) - postprandial , placebo , medicine , overweight , metabolic syndrome , inflammation , lipoprotein , cholesterol , endocrinology , immunology , insulin , obesity , pathology , alternative medicine
Obesity and high level of low density lipoprotein cholesterol (LDL‐C) are considered as major risk factors of the metabolic syndrome and cardiovascular disease. In this study, we hypothesized that an administration of a Lycium chinense (LC) beverage may exert anti‐inflammatory effect in overweight subjects with high LDL‐C level. 53 eligible subjects were randomized to either a LC (n=26) or a placebo (n=27) for 8 weeks in a double‐blinded trial. LC was standardized with anthocyanin. Transcriptomics analysis of inflammatory mediators and signaling molecules, lipid metabolism, blood cell differentiation, plague formation, coagulation, and antioxidant makers were applied using quantitative real‐time reverse transcription‐polymerase chain reaction array. Postprandial plasma level of inflammatory cytokines were assessed by proteomics using Luminex assay. Subjects who consumed a LC for 8 weeks showed a significant down‐regulation of mRNA levels related to oxidation and inflammation compared to the placebo. Consistent results were found in proteomics, showing significant increases of the postprandial plasma levels of tumor necrosis factor‐α and fms‐related tyrosine kinase 3 ligand in the LC compared with the placebo. In addition, 11 subjects were received the postprandial test after co‐administration of a bolus of fat challenge formula and a LC at the final visit. Postprandial blood samples were obtained at 0, 2, 4, 6, and 8 hours after administration and the results will be presented as well. Taken together, these results suggest that daily consumption of a LC beverage may provide a potential health benefits of reducing inflammatory cytokines in subjects overweight and high level of LDL‐C.