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Vitamin B6 status and its relationship with polyunsaturated fatty acid concentrations during pregnancy
Author(s) -
MujicaCoopman Maria,
Farias Dayana,
Brito Alex,
Allen Lindsay,
Kac Gilberto,
Lamers Yvonne
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.919.21
Subject(s) - docosahexaenoic acid , polyunsaturated fatty acid , eicosapentaenoic acid , arachidonic acid , pregnancy , medicine , endocrinology , pyridoxal , chemistry , fatty acid , biochemistry , biology , phosphate , genetics , enzyme
Rationale Suboptimal vitamin B6 status was shown to alter polyunsaturated fatty acid (PUFA) profiles, decreasing plasma (n‐3) and (n‐6) PUFA concentrations, in healthy men and women. Aim To assess the relationships between plasma pyridoxal 5'‐phosphate (PLP) and docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations at different stages of pregnancy. Methods Prospective cohort study in 213 healthy pregnant women (aged 20‐40 y) followed across trimesters at 5‐13, 20‐26 and 30‐36 wk. The study was conducted in Rio de Janeiro, Brazil. Fasting plasma PLP (nmol/L) and serum PUFA (µg/mL) were measured by HPLC and GLC, respectively. Results Plasma PLP concentrations [median (IQR)] dropped from 35.8 (28.4‐43.6) in the 1 st to 21.2 (16.2‐27.1) in the 2 nd trimester ( P <0.0001) and further decreased to 16.9 (12.8‐21.6) in the 3 rd trimester ( P <0.0001). Median (IQR) PUFA concentrations were 55.8 (44.0‐65.5), 70.7 (60.9‐84.7), 74.5 (63.6‐89.6) for DHA; 8.4 (6.6‐11.7), 8.4 (6.5‐12.0), 7.4 (5.2‐10.9) for EPA; and 206 (179‐245), 236 (205‐270), 237 (207‐279) for AA in the 1 st , 2 nd , and 3 rd trimester, respectively. Plasma PLP and DHA were correlated ( P <0.05) in the 1 st ( ρ =0.14) and 2 nd trimester ( ρ =0.20); plasma PLP and EPA ( ρ =0.24) and AA ( ρ =0.18) were correlated in the 2 nd trimester ( P <0.05); no significant correlations were observed between PLP and any PUFA in the 3 rd trimester. Conclusions Plasma PLP concentrations were correlated with DHA, EPA and AA in early pregnancy. Funding: CNPq, FAPERJ, VRF‐FNH‐UBC