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Serum Cytokines are Associated with Colorectal Polyp Number and Type in Adult Males
Author(s) -
Comstock Sarah,
Xu Diana,
Hortos Kari,
Kovan Bruce,
McCaskey Sarah,
Pathak Dorothy,
Fenton Jenifer
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.918.4
Subject(s) - medicine , colonoscopy , gastroenterology , adenoma , colorectal adenoma , colorectal cancer , endocrinology , cancer
Chronic inflammation contributes to colorectal carcinogenesis. To determine if serum cytokines are associated with colon polyps, 126 asymptomatic men (48–65yr) were recruited at colonoscopy. Serum cytokine concentrations were measured by multiplex immunoassay. Odds ratios were determined using polytomous logistic regression for polyp number and type. Males with serum monocyte chemotactic protein‐3 (MCP‐3) or soluble interleukin‐4 receptor (sIL‐4R) concentrations in the lowest tertile were 5 times more likely to have 蠅3 polyps relative to no polyps. For each decrease in serum MCP‐3 or sIL‐4R tertile a man was about 2.5 times more likely to have 蠅3 polyps than no polyps. Males with serum concentrations of interferon‐α2 (IFN‐α2) or interleukin (IL)‐7 in the highest tertile were 3 times more likely to have an adenoma relative to no polyps. Those with serum IL‐8 concentrations in the highest tertile were 4 times more likely to have an adenoma relative to no polyps. For each increase in serum IFN‐α2, IL‐7 or IL‐8 tertile an individual was 1.8 times more likely to have an adenoma than no polyp. Serum concentrations of MCP‐3, sIL‐4R, IFN‐α2, IL‐7 and IL‐8 may indicate which men are more likely to have colorectal polyps and could therefore most benefit from colonoscopy. Support: NIH R03CA142000, MSU Clinical & Translational Sciences Institute