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Influence of exercise training on markers of tumor microenvironment in breast cancer: a comprehensive meta‐analysis from 15 trials
Author(s) -
Ramirez Velez Robinson,
MenesesEchávez José,
González Jímenez Emilio,
RíoValle Jacqueline,
CorreaBautista Jorge
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.916.1
Subject(s) - medicine , breast cancer , meta analysis , oncology , tumor microenvironment , cancer , randomized controlled trial
Objective To establish the influence of exercise interventions on tumor microenvironment‐related markers, including inflammatory cytokines, C‐reactive protein (CRP) and Insulin‐like growth factors (IGF's) in breast cancer survivors. Methods PRISMA statement was followed. MEDLINE, Ovid, EMBASE and CENTRAL were searched for randomized controlled trials until February 2014. Heterogeneity was measured by using the I 2 statistics. A random‐effects models was used in presence of high statistical heterogeneity (I 2 >50%). Meta‐regression analyses were also conducted. Results Data from 15 studies were pooled ( n =1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP, IL‐2, IL‐10, IGF‐I, IGF‐II and IGFBP‐3 ( p <.05). Non‐significant differences were found for IL‐6 and TNF‐α. Meta‐regression models showed that duration (>40 minutes/session) and training intensity (>70% maximum heart rate) of the exercise were predictors of the effects on tumor markers ( p <.05)Conclusions Exercise training exerts favorable effects on tumor microenvironment in breast cancer survivors by improving systemic pro‐inflammatory profile and the serum concentrations of growth markers linked to tumorigenesis. The reductions found for IL‐10 suggest an immunostimulating role of exercise in women with breast cancer.