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MC4R genotype, weight retention and glucose metabolism in women with history of gestational diabetes
Author(s) -
Carvalho Aline,
Liu Huikun,
Zhang Shuang,
Wang Leishen,
Tian Huiguang,
Cheng HangLing,
Li Weiqin,
Zheng Yan,
Huang Tao,
Hu Gang,
Qi Lu
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.915.1
Subject(s) - gestational diabetes , medicine , endocrinology , carbohydrate metabolism , diabetes mellitus , genotype , pregnancy , body mass index , postpartum period , type 2 diabetes , gestation , biology , genetics , gene
Background MC4R genotype has been related to adiposity, glucose metabolism and risk of GDM. We aimed to test whether MC4R genotype modify postpartum weight retention on glucose metabolism biomarkers at postpartum among women with history of gestational diabetes mellitus (GDM). Methods and materials We analyzed glucose metabolism biomarkers (HOMA‐IR, fasting glucose, 2 hours glucose and HbA1c) at 1‐5 years after delivery in 1208 Chinese women with prior GDM. Postpartum retention weight was calculated by weight change from pre‐pregnancy to postpartum 1‐5 years. We genotyped GWAS‐identified MC4R rs6567160. Results The mean of weight retention was 2.8kg (95% CI: 2.4; 3.1kg). The frequency of adiposity‐increasing allele (C) of SNP rs6567160 was 23%, and it was significantly associated with a 0.09% higher postpartum HbA1c (p=0.014) after adjustment for age and BMI. In addition, we found significant interactions between MC4R genotype and weight retention on 2 hours glucose levels (β=0.023 p=0.003) and HOMA‐IR (β=‐0.055 p=0.035) after adjustment for age, BMI and follow‐up year. Conclusion Our data indicate that MC4R genotype is related to glucose metabolism, and interact with postpartum weight retention in women with history of GDM.