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Changes in Microbiome Profiles and Nutrient Absorption in Intestine by Soy Protein
Author(s) -
Lim Jinkyu,
Kim Sunghee,
Choi Jaesun,
Chen Xiaocen
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.914.5
Subject(s) - protease , soy protein , microbiome , proteases , digestion (alchemy) , food science , biology , nutrient , bacteria , metagenomics , small intestine , biochemistry , chemistry , enzyme , bioinformatics , ecology , genetics , chromatography , gene
Soybean has good nutritious values with high content of proteins cultivated all over the world. Form our previous studies, we found that soy protein is resistant to in vitro digestion by proteases from digestive tract, bacteria and fungi. We call the protease resistant soy protein or protease resistant food protein (PRFP) and assume that the PRFPs interact with the intestinal tracts, nutrients, or microbes in the intestine to influence the physiological status of the body. We tested the interaction between PRFP and microbes, and nutrients, such as cholesterol and triglyceride. The interference of the fluorescence labeled bacteria‐intestinal cell interaction was shown in the presence of soy proteins. Plus, we observed the structural change in the microvilli of small intestine of mice led soy diet. For the preliminary studies, we also analyzed the microbiome profiles in the fees of the mice fed soy proteins using metagenomic sequencing. This study suggests that soy protein is a good source of nutrient but also a biological polymer to influence physiological change and microbiome changes.