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Associations Between Markers of Inflammation and Hemoglobin Concentration: Implications for Diagnosis of Anemia in Women of Reproductive Age
Author(s) -
Ashour Fayrouz,
Addo Yaw,
Sullivan Kevin,
Suchdev Parmi,
Mei Zuguo,
Temple Victor,
Raiten Daniel,
FloresAyala Rafael
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.913.3
Subject(s) - anemia , hemoglobin , medicine , inflammation , c reactive protein , systemic inflammation , gastroenterology , physiology , immunology
Inflammation reduces Hb concentrations, increasing anemia estimates, but the magnitude of this effect in different populations is unknown. We explored associations between inflammation (defined as C‐reactive protein (CRP) > 5mg/L and/or α1–acid glycoprotein (AGP) >1g/L), Hb concentrations, and their interpretation in defining anemia (Hb <120 g/L) in women of reproductive age (WRA). Data from 10,483 non‐pregnant WRA who participated in national surveys in 8 countries were analyzed using complex survey techniques by the Biomarkers Reflecting Inflammation and Nutrition Determinants of Anemia (BRINDA) project. Anemia prevalence was 27.6%, and inflammation ranged from 7.8% to 28.9%. Hb was inversely correlated with CRP and AGP. Anemia prevalence was 2 times higher in those with elevated AGP compared to normal (POR 2.0, 95% CI: 1.7–2.3) which remained unchanged after adjustment for age and BMI. The association between inflammation and anemia based on elevated CRP was weaker, POR 1.2 (95% CI: 1.1 –1.4) but not significant in Laos, Oman or Papua New Guinea. Elevated CRP and AGP were independently associated with a higher prevalence of anemia. Approaches to account for elevated CRP and AGP in estimating anemia prevalence will be presented. Research support: BMGF, CDC, GAIN, NICHD.