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Innate Immune Sensing of a Bacterial Protein in the ER of the Intestine by IRE1b
Author(s) -
Cho Jin,
Lencer Wayne
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.913.1
Subject(s) - endoplasmic reticulum , innate immune system , microbiology and biotechnology , golgi apparatus , immune system , inflammation , organelle , biology , unfolded protein response , immunology
The plasma membrane and all membrane‐bound organelles except for the Golgi and endoplasmic reticulum (ER) are equipped with pattern‐recognition molecules to sense microbes or their products and induce innate immunity for host defense. Here, we report that Inositol‐REquiring‐1b (IRE1b), an intestinal epithelial cell‐specific ER membrane protein, is activated to induce inflammation by Cholera toxins and Shiga toxins as they co‐opt the ER to cause disease such as inflammatory bowel disease. This inflammatory response depends on the RNase activity of IRE1b. These observations implicate Regulated IRE1a‐Dependent Decay of mRNA (RIDD) in a novel innate immune mechanism of host defense originating from within the ER lumen of the intestine.