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Plasma Nutrient Biomarkers are Associated with Waist‐to‐Height Ratio in Youth with Type 1 Diabetes: SEARCH for Diabetes in Youth Nutrition Ancillary Study
Author(s) -
Wang Shanshan,
Crandell Jamie,
Couch Sarah,
King Irena,
Lawrence Jean,
Dabelea Dana,
Lamichhane Archana,
Kim Grace,
Bell Ronny,
Zhu Shankuan,
MayerDavis Elizabeth
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.906.33
Subject(s) - medicine , linoleic acid , endocrinology , type 1 diabetes , type 2 diabetes , obesity , palmitic acid , diabetes mellitus , confounding , vitamin d and neurology , fatty acid , chemistry , biochemistry
Background Plasma nutrient biomarkers may be associated with waist‐to‐height ratio (WHtR) in youth with type 1 diabetes (T1D). Design 1,416 youth aged 3‐20 years at diagnosis were included at baseline and 1,178 youth had a follow‐up visit after 23 (range 16‐40) months. Data on plasma phospholipid fatty acids, desaturase activities and vitamins were obtained at baseline. Multiple linear regression was used with adjustment for demographic and diabetes‐related confounders. Findings were stratified by weight status when significant (P<0.05) effect modification was observed. Results In cross‐sectional analysis, palmitic acid (P=0.001), dihomo‐γ‐linolenic acid (DGLA, P=0.003) and Δ6‐desaturase (D6D, P=0.0004) were positively; oleic acid (P=0.014), linoleic acid (LA, P=0.002) and vitamin D (VD, P<0.0001) were negatively associated with WHtR. In normal weight youth, VD (P=0.003) was negatively associated with WHtR. In obese youth, DGLA (P<0.0001) and D6D (P<0.0001) were positively; Δ9‐desaturase‐18 activity (P=0.011) and VD (P<0.0001) were negatively associated with WHtR. In longitudinal analysis, baseline LA (P=0.017), n‐6/n‐3 fatty acid ratio (P=0.017), VD (P=0.003) and vitamin E (P=0.0001) were negatively associated with WHtR at follow‐up only in obese youth. Conclusions Plasma nutrient biomarkers are associated with WHtR in T1D youth, most commonly among those who are obese.