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Coffee Consumption and Risk of Lung Cancer in the NIH‐AARP Diet and Health Study
Author(s) -
Guertin Kristin,
Freedman Neal,
Loftfield Erikka,
Graubard Barry,
Caporaso Neil,
Sinha Rashmi
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.906.28
Subject(s) - lung cancer , medicine , hazard ratio , proportional hazards model , environmental health , tobacco smoke , demography , smoke , cancer , confidence interval , physics , sociology , meteorology
Background Coffee drinkers had higher risk of lung cancer in some previous studies, however as heavy coffee drinkers tend to be cigarette smokers, such findings could be confounded. Therefore, we examined this association in the nearly half‐a‐million participants of the US NIH‐AARP Diet and Health Study. Methods Typical coffee intake and smoking history were queried at baseline. During 4,155,256 person‐years of follow‐up, more than 9000 incident lung cancer cases occurred. We used Cox proportional hazards regression to estimate hazard ratios and 95% CIs for coffee intake and risk of subsequent lung cancer. We also comprehensively adjusted for tobacco smoking and examined associations by detailed strata of tobacco use. Results Coffee drinkers were far more likely to smoke than non‐drinkers. Although coffee drinking was associated with lung cancer in age‐ and sex‐ adjusted models (蠅6 cups/day: 4.56, 4.08‐5.10), this association was substantially attenuated after adjusting for smoking (1.27, 1.14‐1.42). Similar findings were found for each different histologic type of lung cancer and for participants drinking predominantly caffeinated or decaffeinated coffee. Little evidence for an association was observed in our stratified analyses, either within never smokers or most categories of tobacco use. Conclusions Although we cannot exclude a modest positive association between coffee drinking and lung cancer, our results do not provide evidence for a strong association.