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Circulating folate levels and colorectal adenoma: a meta‐analysis
Author(s) -
Youn Jiyoung,
Lee Jung Eun
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.906.22
Subject(s) - colorectal adenoma , medicine , meta analysis , adenoma , randomized controlled trial , confidence interval , gastroenterology , placebo , relative risk , colorectal cancer , oncology , pathology , cancer , alternative medicine
To investigate the effect of folate on colorectal neoplasia, we conducted a meta‐analysis of epidemiologic studies and examined whether circulating folate levels were associated with colorectal adenoma. We searched the relevant published articles through the PubMed databases and also identified the reference lists of the retrieved articles. We also included our case‐control study examining the relation between circulating folate levels and colorectal adenoma in Korean adults. The study‐specific relative risks (RRs) and 95% confidence intervals (CIs) from individual studies were pooled using a random‐effects model and heterogeneity were analyzed using I2 statistic. Two cross‐sectional, four case‐control, and four randomized trial studies were included in the present meta‐analysis. We included only placebo group from randomized trial studies of folic acid supplementation. We observed a significant inverse association for colorectal adenoma (combined RR = 0.77; 95% CI, 0.66‐0.87), comparing the top versus bottom categories of circulating folate levels. When we limited our analysis to clinical trials of recurrent adenoma, the combined RRs (95% CIs) comparing the top with the bottom categories were 0.68 (95% CI: 0.54‐0.82). The findings from this meta‐analysis suggest the evidence that circulating folate levels has an inverse association with colorectal adenoma.