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Relationship between Microalbuminuria and Serum Vitamin D Levels in African Americans with Type 2 Diabetes
Author(s) -
Zarini Gustavo,
Shaban Lemia,
Exebio Joel,
Vaccaro Joan,
Ajabshir Sahar,
Huffman Fatma
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.902.6
Subject(s) - microalbuminuria , medicine , bonferroni correction , type 2 diabetes , vitamin d and neurology , post hoc analysis , post hoc , diabetes mellitus , endocrinology , gastroenterology , mathematics , statistics
This cross sectional study examined the relationship between microalbuminuria (MA) and serum 25‐hydroxyvitamin D [25(OH)D] levels in African Americans with type 2 diabetes (T2D). Participants (n=129) were recruited from multiple sources from South Florida. MA was determined in urine samples by a semi‐quantitative assay (ImmunoDip, Diagnostic Chemicals Limited, Oxford, CT, US). Serum 25(OH)D levels were determined using a commercial ELISA kit from Immunodiagnostic Systems Limited (Scottsdale, AZ, US). Glycosylated hemoglobin (A1C) levels were measured from whole blood samples with the Roche Tina‐quant method. Statistical analysis included t‐test, chi‐square, General Linear Model (GLM) and Bonferroni post‐hoc test, controlling for age, gender, BMI, A1C and hypertension medications. MA was present in 40 (31%) of African Americans with T2D. There was a statistically significant difference in 25(OH)D levels between participants with and without MA (F(1,121) = 9.72, p = 0.002). Bonferroni post‐hoc test revealed that those with MA had significantly (p = 0.002) lower 25(OH)D levels (M = 39.5, SD = 13.8) as compared to those without MA (M = 51.5, SD = 23.4). Lower vitamin D levels might exacerbate kidney dysfunction in African Americans with T2D. Funding for this research was provided through an NIH/NIDDK sponsored grant.