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Total Energy Expenditure of Infants with Congenital Heart Disease Post‐surgical Intervention
Author(s) -
Trabulsi Jillian,
Irving Sharon,
Papas Mia,
Hollowell Chelsea,
Ravishankar Chitra,
Stallings Virginia,
MedoffCooper Barbara
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.901.7
Subject(s) - medicine , pediatrics , heart disease , total energy expenditure , energy expenditure , doubly labeled water , cardiology
Background Growth failure is common in infants with congenital heart disease (CHD), however it is unclear if it is due to increased total energy expenditure (TEE). Objectives To determine if TEE of infants with CHD post‐surgical intervention differs from healthy infants, and evaluate the accuracy of equations used to calculate TEE. Design Infants with CHD and surgical intervention within 30 days of life, and healthy 3‐ and 12‐month old infants, were enrolled. TEE was measured via doubly labeled water at 3‐months (n=15 CHD, 12 healthy) and 12‐months (n=11 CHD, 12 healthy). Multiple linear regression models were fit to examine the association between health status (CHD vs. healthy) and TEE. Regression/summary statistics were used to assess accuracy of equations for calculating TEE. Results 3‐month TEE did not differ significantly between CHD vs. healthy infants; TEE was 36.4 kcal/day higher for CHD vs. healthy (95% CI: ‐46.3, 119.2 kcal/day; p=0.37). 12‐month TEE was also not significantly different, with CHD 31.7 kcal/day higher than healthy (95%CI: ‐71.5, 134.8; p=0.53). The 2002 DRI equation had the smallest difference between calculated and measured TEE (mean difference 79 kcal/d); the 1989 RDA had closest agreement (R 2 =0.62, p<0.001) to measured TEE. Conclusions TEE in infants with CHD post‐surgical intervention was not greater than healthy infants at 3 and 12 months. When calculating TEE of CHD infants 蠄12 months post‐surgery, the 2002 DRI/1989 RDA equations are most accurate. Support: NIH R01‐NR002093, MO1‐RR00240, UL1‐RR024134.