Premium
Aluminum and other metal content of oral pediatric medications
Author(s) -
Yokel Robert,
Seger Sarah,
Unrine Jason
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.901.10
Subject(s) - dietary reference intake , medical prescription , tolerable daily intake , medicine , reference daily intake , bioavailability , food and drug administration , oral administration , toxicity , environmental chemistry , chemistry , toxicology , zoology , body weight , pharmacology , environmental health , biology , organic chemistry , nutrient
The objective was to determine the concentrations of aluminum and other potentially toxic metals in representative common oral medications administered to healthy American infants and to evaluate if toxic levels might be administered with normal use. An oral rehydration solution, nine non‐prescription medications, and four prescription medications were prepared for determination of Al, Cd, Cr, Co, Cu, Pb, Mg, Mn, Se, Ag, Sr, U, V, and Zn by ICP‐MS. The amount of toxic metals in the maximum recommended dose for one week's administration of each pharmaceutical was calculated and compared to reported tolerable upper intake levels or permissible weekly exposures. Calculations were based on a 7.6 kg infant, average for a 6 month old. Al was < 1% of the Joint Food and Agriculture Organization of the UN/WHO provisional tolerable weekly intake. Cd was < 2.5%, Cu and Pb < 5%, and V < 1% (except for the rehydration solution [~ 11%]) of the United States Pharmacopeia permissible daily exposure in all samples. Sr was < 1% of the EPA oral reference dose for toxicity. Ag was below the limit of detection in most samples. An ultratrace amount of U was detected in only one product. No products provided > 5% of the recommended weekly allowance of Mg or > 25% of Se, or > 25% of the tolerable upper limit of Mn. Some products provided > 100% of the adequate intake of Cr. No concerns for metal toxicity were uncovered in these results. Supported by The Pharmaceutical Sciences Department and Office of the Dean, College of Pharmacy, University of Kentucky.