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Markers of Environmental Enteric Dysfunction (EED) are Associated with Neurodevelopment in Tanzanian Children
Author(s) -
Etheredge Analee,
Manji Karim,
McDonald Christine,
Kellogg Mark,
Tran Hao,
Gosselin Kerri,
Gewirtz Andrew,
Kisenge Rodrick,
Aboud Said,
Bellinger David,
Fawzi Wafaie,
Duggan Christopher
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.899.1
Subject(s) - medicine , flagellin , odds ratio , gastroenterology , pediatrics , immunology , receptor
Background Children with environmental enteric dysfunction (EED) are at increased risk for impaired growth and neurodevelopment. We conducted a study to evaluate novel biomarkers of gastrointestinal epithelial and barrier function associated with EED as predictors of neurodevelopment. Methods Blood samples were obtained from 107 Tanzanian infants at 6 weeks and 6 months for assay of serum citrulline (CIT) and antibodies to LPS and flagellin. Neurodevelopmental testing (Bayley Scales of Infant Development‐III) was conducted at 15 months of age. Results The log odds of having a below‐median raw expressive language score (< 20) was increased by 1.66 (p=0.03) for every 1 unit increase (1‐UI) in LPS IgA at 6 weeks and by 0.19 (p=0.04) per 1‐UI in CIT at 12 months; log odds were decreased by 1.54 (p=0.02) per 1‐UI in flagellin IgG and by 0.16 (p=0.02) per 1‐UI in CIT at 6 months. Conclusion Higher levels of LPS‐IgA at 6 weeks and CIT at 12 months, and lower levels of flagellin‐IgG and CIT at 6 months were associated with below‐median language scores. Markers of intestinal permeability and absorption are indicators of neurodevelopmental sequelae in children at risk of EED. Funding NICHD (R01 HD048969; K24HD058795),Bill and Melinda Gates Foundation (OPP1066203)