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New α‐(N)‐Heterocyclic Thiosemicarbazones Compounds Including The Cu 2+ And Pd 2+ Complexes: Applications Towards Potential Anti‐Cancer Agents
Author(s) -
Scott Rebekah,
McGill Bradley,
Carroll William,
Lisic Edward
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.897.18
Subject(s) - heteronuclear molecule , chemistry , heteronuclear single quantum coherence spectroscopy , imidazole , metal , two dimensional nuclear magnetic resonance spectroscopy , semicarbazone , nuclear magnetic resonance spectroscopy , nmr spectra database , stereochemistry , combinatorial chemistry , nuclear chemistry , medicinal chemistry , spectral line , organic chemistry , physics , astronomy
Our research team has synthesized new compounds involving the reaction of α‐(N)‐heterocyclic substrates, including methyl‐imidazole‐2‐carboxaldehyde, with several commercially available thiosemicarbazides (TSC's) to form many new α‐(N)‐heterocyclic thiosemicarbazone compounds, which act as tridentate monoanionic ligands with Cu 2+ and Pd 2+ . These ligands were synthesized in the lab, recrystallized, and analyzed via ¹H NMR and ¹³C NMR spectroscopy using ¹H detected ¹³C and 15N Heteronuclear Single Quantum Coherence (HSQC) and Heteronuclear Multiple‐Bond Correlation (HMBC) experiments. The NMR spectra show evidence for the proposed structures for the ligands. We have performed anti‐proliferative MIC (minimum inhibitory concentration) studies using seven different microbes with the ligands and the metal complexes in order to determine the anti‐microbial properties of each TSC compound synthesized, and have found that the Cu and Pd metal complexes of these ligands have significant anti‐proliferative activities. We relate these anti‐microbial properties to activity against Topoisomerase IIa.