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Comparative Effects of Avocado Oil and Losartan on Brain Mitochondrial Function and Calcium Transport in Hypertensive Rats
Author(s) -
CabreraNuñez Noemi Faride,
GarciaBerumen Claudia Isabel,
Hernandez de la Paz Jose Lucio,
RayaFarias Andres,
CalderonCortes Elizabeth,
SaavedraMolina Alfredo,
SalgadoGarciglia Rafael,
CortesRojo Christian
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.896.7
Subject(s) - losartan , mitochondrion , oxidative stress , respiration , endocrinology , calcium , medicine , chemistry , mitochondrial respiratory chain , oxidative phosphorylation , pharmacology , angiotensin ii , biology , biochemistry , blood pressure , botany
Ca 2+ participates as a second messenger in a myriad of metabolic and physiologic processes in the brain, with mitochondria controlling Ca 2+ transients through its uptake and release. Hypertension (HT) is known to impair mitochondrial Ca 2+ homeostasis in association with respiratory chain dysfunction. As many of the deleterious effects of HT are related with increased oxidative stress, the goal of this study was to assess whether avocado oil, an important source of antioxidants, prevent the deleterious effects of HT in brain mitochondrial calcium handling and mitochondrial function and to compare its effects with losartan, an antihypertensive drug. Ca 2+ uptake and release was decreased in L‐NAME‐induced HT rats and this effect was fully prevented by losartan, with avocado oil dietary intake exhibiting a slight protective effect. In mitochondria from control rats, respiration was negatively modulated by 40µM Ca 2+ and this effect was absent in mitochondria from hypertensive rats. Modulation of respiration by Ca 2+ was recovered either by losartan or avocado oil. These results suggest that losartan improves the modulatory effects of Ca 2+ in mitochondrial function by preventing the impairment in mitochondrial Ca 2+ handling, while avocado oil exert the same effect of losartan on the modulation of mitochondrial function without having an apparent effect on Ca 2+ handling. Supported by CONACYT ( 130638 to CCR ) and CIC‐UMSNH ( CCR ) grants