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Therapeutic Effects of Pure Aloe Vera Gel on Alloxan‐Induced Diabetic animal models.
Author(s) -
Imaga Ngozi,
Obominiru G,
Oyadina O,
okafor uzoma
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.884.64
Subject(s) - aloe vera , alloxan , animal model , traditional medicine , diabetes mellitus , pharmacology , chemistry , medicine , endocrinology
Aloe vera gel (AVG) extract is commonly used as a home remedy for some diseases, including diabetes mellitus. This study investigates the effects of pure A loe vera ( Aloe babardensis) gel on some biochemical, haematological and histological parameters in diabetic rats. The animals were divided into six groups of six rats each (n=6). Diabetes mellitus was experimentally induced in rats by intraperitoneal administration of a single dose of alloxan monohydrate (170 mg/kg BW.) following a 12 h fasting period. The Groups I and V received isotonic saline in a similar manner. The establishment of diabetes mellitus was confirmed by fasting blood glucose (FBG) levels above 350mg/dl using a Gluco‐Metre (Accu‐Chek Active). The AVG extract was administered for 14 days at. All the drugs were administered. Blood samples were collected from fasted rats. The effects of AVG on fasting blood biochemical, haematological and oxidative stress parameters in the liver and histological examination of the liver, kidney and pancreas were evaluated. Results indicated a decrease in glucose level in the AVG‐treated group and an improvement in the lipid profile, as well as some haematological parameters. In addition, oral administration of Aloe barbadensis gel decreased the level of MDA with a corresponding increase in the activities of CAT, SOD, GST and GSH levels in the liver tissue of diabetic rats. These results suggest potent hypoglycaemic, hypolipidemic, antioxidant and restorative effects of Aloe. Thus indicating that Aloe vera can be used as an alternative remedy for treatment/management of diabetes mellitus.