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Serum cytokine, chemokine and hormone levels in Saudi adults with pre‐diabetes: a one‐year prospective study
Author(s) -
AlDaghri Nasser,
Ajlan Abdulrahmam,
Alfawaz Hanan,
Yakout Sobhy,
Aljohani Naji,
Kumar Sudhesh,
Alokail Majed
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.884.13
Approximately 5–10% of subjects with pre‐diabetes eventually progress to diabetes every year. While inflammation is thought to be involved in the development of obesity‐related type 2 diabetes mellitus (T2DM), the relation between inflammation and pre‐diabetes remains largely unexplored. In this study we examined a comprehensive panel of 10 serum biomarkers involved in overweight and obese subjects with pre‐diabetes. A total of 98 subjects (23 males, 75 females) were advised to reduce total intake of fat, increase fiber intake and physical activity. Serum cytokines, MCP and other hormones were assessed by multiplex cytokine profiling. CRP, IL‐6, leptin, IL‐10, MCP, resistin, serpin, and TNF‐α were significantly lower after 12‐months than baseline. Serum concentrations of other adipocytokines, including adipsin and leptin were modestly lower in the 12‐month follow‐up than baseline, but failed to reach statistical significance. Changes in HbA1c was found to be positively correlated with adipsin, CRP, IL‐6, IL‐10, resistin, serpin, and TNF‐α. The results suggest that promotion of lifestyle changes for one year among overweight and obese subjects modestly changes several circulating inflammatory biomarkers which maybe favorable in reducing risk for T2DM progression.