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Effects of Quercetin in IL‐6 and TNF‐α Levels in Diabetic Rats
Author(s) -
Gergerlioglu Hasan,
Demir Enver,
Alp Muhammed,
Oz Mehmet
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.856.3
Subject(s) - quercetin , streptozotocin , tumor necrosis factor alpha , diabetes mellitus , medicine , flavonoid , interleukin , endocrinology , interleukin 6 , proinflammatory cytokine , pharmacology , chemistry , inflammation , cytokine , biochemistry , antioxidant
We aimed to investigate the effects of quercetin, a natural flavonoid, on plasma interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) levels which are the pro‐inflammatory cytokines. Following the induction of diabetes with streptozotocin (60 mg/kg, i.p.), 45 adult male rats (16 – 18 weeks) were objected to either 50 mg/kg/day or 100 mg/kg/day quercetin injection for 21 days. Plasma IL‐6 and TNF‐α levels were measured with enzyme‐linked immunosorbent assay. All experimental procedures were conducted with approval of local ethical committee which has regulations in accordance with Statement of Principles for the Use of Animals in Research & Education of FASEB. We found that both doses of quercetin ameliorated plasma IL‐6 and TNF‐α levels in diabetic rats. There was no difference of investigated parameters between quercetin applied and control groups in non‐diabetic rats. Conclusively, quercetin seems to be an immulomodulator rather than an immuosupressant in the diabetics.