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Perinatal Exposure to Brominated Flame Retardants Reduces Social Recognition Ability in Adult Male Mice
Author(s) -
Gonzalez G,
Valdez M,
Gutierrez R,
Valdez J,
McLaughlin T,
Cherukury H,
Chen H,
LeonOlea M,
CurrasCollazo M
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.840.7
Subject(s) - open field , corn oil , polybrominated diphenyl ethers , elevated plus maze , lactation , juvenile , gestation , zoology , psychology , biology , pregnancy , endocrinology , psychiatry , ecology , anxiety , genetics , pollutant
Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants associated with cognitive/attention deficits in children. We evaluated behaviors relevant to autism spectrum disorder (ASD) in progeny of C57Bl6 dams dosed with an environmentally relevant industrial PBDE mixture, DE‐71, during pre‐conception (4 wk), gestation (3 wk) and lactation (3 wk). Dosing consisted of 1) low dose (0.1 mg/kg/d), 2) high dose (0.4 mg/kg/d), or 3) corn oil vehicle (control) via ingestion of infused corn flakes. The exposed progeny were subjected to behavioral tests: Juvenile Play (PND 20), Sociability (PND 21), Open Field Test (PND 30‐40), Marble Burying (PND 40‐50), Social Recognition Ability (PND 55‐60), and Elevated Plus Maze (PND 60‐65). The social recognition test revealed significant preference for the novel conspecific in control males (F 1,23 =7.38, p<0.05) and control females. In comparison, male low dose PBDE mice showed no preference but this was not due to reduced sociability using a 3‐chamber sociability test. For marble burying high dose DE‐71 decreased repetitive behavior in males and females (F 2,54 =5.96, p<0.005). Distance traveled in the open field was significantly greater in high dose PBDE males (p<0.05). Our findings suggest that developmental exposure to PBDEs may produce neurobehavioral deficits related to ASD. Supported by APS, MARC, UCMEXUS, NSF and Sigma Xi Research Society.