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Cerebral Blood Flow Regulation Following Inhalation of Nicotine via Electronic Cigarettes
Author(s) -
Colby Hannah,
Sprick Justin,
Pham Grace,
Cooke William,
Fogt Donovan,
Rickards Caroline
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.833.1
Subject(s) - nicotine , cerebral blood flow , anesthesia , blood pressure , middle cerebral artery , placebo , cerebral autoregulation , inhalation , medicine , mean arterial pressure , heart rate , cardiology , autoregulation , ischemia , pathology , alternative medicine
Background The use of electronic cigarettes (e‐cigarettes) is growing rapidly but the physiologic effects of vaporized nicotine are relatively unknown. We hypothesized that acute inhalation of vaporized nicotine via e‐cigarettes would impair regulation of cerebral blood flow (CBF) in response to variations in arterial pressure (cerebral autoregulation, CA). Methods: 13 subjects (6 F; 7 M) inhaled vapor from an 18 mg nicotine (nicotine) or a 0 mg nicotine (placebo) e‐cigarette on separate days (randomized). Heart rate (HR), mean arterial pressure (MAP), mean middle cerebral artery velocity (MCAv), and cerebral oxygen saturation (S C O 2 ) were measured non‐invasively. Oscillatory lower body negative pressure (OLBNP) between 0 and ‐60 mmHg was applied for 20 cycles at 0.05 Hz and 0.10 Hz. Results: Between placebo and nicotine conditions, baseline MAP, MCAv, S C O 2 , and HR were similar (P蠅0.21). MAP and ScO 2 very low frequency (VLF; 0.04‐0.07 Hz) power with 0.05 Hz OLBNP, and low frequency (LF; 0.07‐0.2 Hz) power with 0.1 Hz OLBNP were higher under the placebo condition (P蠄0.03‐0.06). Cross‐spectral analysis in the LF (with 0.1 Hz OLBNP) and VLF (with 0.05 Hz OLBNP) revealed that gain between MAP‐MCAv was similar between conditions (P蠅0.128). MCAv‐ScO 2 and MAP‐ScO 2 coherences were <0.5 under all conditions, so gain values are not reported. Conclusion These data suggest that nicotine, when acutely inhaled via e‐cigarettes, does not impair the cerebral pressure‐flow relationship. Funding: University of Texas at San Antonio (UTSA) Collaborative Seed Grant.