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Long Term Capsaicin Administration Effects on Skeletal Muscle Function in Aging Mice
Author(s) -
Benson Marisa,
Receno Candace,
Le Angela,
Ruby Sarah,
Liang Chen,
DeRuisseau Lara,
DeRuisseau Keith
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.825.10
Subject(s) - capsaicin , skeletal muscle , sarcopenia , endocrinology , medicine , muscle atrophy , chemistry , muscle mass , atrophy , receptor
The decline in muscle mass and quality with aging, termed sarcopenia, can decrease physical function and affect overall quality of life. Administration of capsaicin can activate transient receptor potential vanilloid 1 receptors and attenuate disuse‐mediated muscle atrophy. However, potential benefits of capsaicin on aging skeletal muscle are unknown. We tested the hypothesis that long term capsaicin administration would attenuate decreases in skeletal muscle mass and function that occur with aging. Twenty‐three month old male C57BL/6J mice received diets (AIN‐93G) ad libitum containing capsaicin emulsified in lecithin (C; 50 mg/kg food weight; n=12) or lecithin (L; n=12) for 8 weeks. Animals were anesthetized and the extensor digitorum longus was extracted and vertically suspended in a Kreb's‐Ringer buffer and maintained at 25°C to assess contractile properties. Animal body mass, muscle mass and contractile characteristics were analyzed using an independent samples t‐test. Data are expressed as mean±SEM. Animal body and muscle mass were similar between groups (p>0.05). Maximal force generation did not differ (p>0.05) between groups (C: 10.13±1.35 N/cm 2 ; n=6 vs. L: 9.37±1.91 N/cm 2 ; n=9). Fatigue resistance, reported as a percentage of initial force generation following 30 seconds of contractions, was not different between groups (C: 39.02±1.52; n=4 vs. L: 42.2±2.50; n=9; p>0.05). Thus, preliminary data do not support the hypothesis that long term capsaicin administration attenuates the aging‐associated loss in skeletal muscle mass and contractile dysfunction.
Funding: LMC Student Research Committee; McDevitt Center Research Fellowships in Natural Science to AL and SR.